Your tissues, your cells, your DNA — to function well, they all needfolate。In fact, this natural form of vitamin B9 is crucial. But not everyone gets enough of it.
We spoke to Lisette Breto, PharmD, a clinical pharmacist with Banner Health, about folate and folic acid. She explained how folate deficiency may be connected to other medical conditions, which groups should boost their folate intake, and the important differences between folate and叶酸。
What is folate?
Folate helps in the making of DNA and other genetic material. Folate shows up in lots of different foods, including:
- 芦笋
- 牛油果
- Bananas
- Beets
- Black beans
- Broccoli
- Brussels sprouts
- Edamame
- Eggs
- 扁豆
- 坚果和种子
- Spinach
- 橘子
Folic acid, meanwhile, is the synthetic version of folate. Dr. Breto explained that in 1998, the U.S. Food and Drug Administration (FDA) approved fortifying certain foods with folic acid, such as cereal, flour, and bread, to decrease risk of neural tube defects (NTD). Because certain foods are now fortified with folic acid, Dr. Breto said it’s now uncommon in the U.S. for someone to have low folate. Instead, it can show up with or be the result of other medical conditions.
When your folate levels are low, you might have symptoms like those ofanemia: feeling fatigued, lethargic, out of breath or lightheaded.
谁得到叶酸缺乏症？
国家卫生研究院（NIH），概述了以下几年，通常面临风险folate deficiency:
- People with alcohol use disorder
- Women of childbearing age
- Pregnant women
- People with malabsorptive disorders
- 人MTHFR多态性
With some of these groups, low folate usually comes from poor folate absorption. Dr. Breto also mentioned that for some people it can be due to poor nutrition or a restricted diet.
研究人员have also studied low folate’s possible role in conditions likeAlzheimer’s disease,高血压, and autism spectrum disorder, but results have so far been inconclusive.
Can I get too much folate/folic acid?
Yes! But it really only happens with folic acid — not folate — since folic acid doesn’t always fully metabolize. For some folks, that metabolizing process is slow. And when too much folic acid builds up in your bloodstream, it can cause an undetectable vitamin B12 deficiency. It can also mask or hide a vitamin B12 inducedmegaloblastic anemia, a condition where your bone marrow produces unusually large and abnormal red blood cells。这种掩蔽可能是危险的，因为B12缺乏不仅仅是引起贫血;它也可能导致严重的神经损伤。
可作为5-MTH的活性形式的维生素B9，可购买作为补充剂。Breto博士解释说，这些补充剂可以与其他药物相互作用，因此涉及您的医疗保健提供者是重要的。
It’s easy to mistakenly think folate and folic acid are interchangeable terms, Dr. Breto said. But some folks may benefit more from one than the other. She mentioned that the following groups are more likely to be prescribed folic acid supplements.
- Pregnant women
- Women of childbearing age
- Tobacco smokers
- People with chronic alcohol abuse disorder
- 营养不良的人
- People with gastrointestinal or malabsorptive disorders
- People on hemodialysis
When should I involve my doctor?
The answer is simple: always.
Your health care provider can help determine how much folate or folic acid is best for you. Reviewing your medical history is an important part of dialing in the right amount. And because low folate levels may relate to other medical conditions, getting medical guidance for these other conditions will help your folate levels.
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